The aim of the study is to quantify the ex vivo induction of apoptosis by ABT-737 + association platinum in samples exposed and demonstrate the value of this combination compared to the agents used alone. As ABT-737 triggers programmed cell death in a BAX/BAK-dependent manner, we provide preclinical evidence that the efficacy of ABT-737 as a single agent is self-limiting in SCLC, but the addition of rapamycin can maintain or increase levels of BAX protein and markedly enhance the anticancer efficacy of ABT-737. The highly potent BH-3 mimetic, ABT-737, is the leading member of a new class of small-molecule drugs that is approaching or entering early clinical trials for cancer treatment (6). The prototype BH3 mimetic ABT-737 selectively targets the three prosurvival proteins BCL-XL, BCL-2, and BCL-W (but not MCL-1 or A1) and its oral derivative ABT-263 has proved promising in clinical trials. Some putative BH3 mimetics are also tested clinically while others are still being characterized. ABT-737 is a BH3 mimetic compound that selectively targets BCL2 and BCLX L. In the present work, we report that ABT-737 is highly effective (LC 50 <50 n M) as a single agent against most (21/30) Abstract The novel anticancer drug ABT-737 is a Bcl-2 Homology 3 (BH3)-mimetic that induces apoptosis by inhibiting pro-survival Bcl-2 proteins.
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Learn how to gather details about your cancer, places to search for clinical trials, how to narrow your search, and questions to ask to help you find a trial that is appropriate for you. Steps to Find a Clinical Trial Learn how to find the Learn more about clinical trials and research at the Brady Urological Institute. We continue to monitor COVID-19 cases in our area and providers will notify you if there are scheduling changes. Please continue to call your providers with he Physicians and researchers at Johns Hopkins Medicine are constantly engaging in clinical trials to further the understanding and treatment of diseases and conditions of the heart and vascular system. We continue to monitor COVID-19 cases in NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying capmatinib.
Examples of HIV/AIDS clinical trials underway include studies of new HIV medicines, studies of vaccines to prevent or treat HIV, and studies of medicines to treat infections related to HIV. 2020-01-02 Join us on Oct. 16 from 10 am to 11 am to discuss remote patient monitoring and its role in preserving the continuity of pediatric clinical trials amid the COVID-19 pandemic and beyond.
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ABT-737 induces dose-dependent impairment of maximal O 2 consumption rate in B-cell lymphoma cells. ABT-737 induces apoptosis and synergizes with chemotherapy,and disrups BCL-2/BAX heterodimerization and induces BAX conformational change in AML cells.
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ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a potential cancer chemotherapy ,  it was subsequently identified as a senolytic (a drug that selectively induces cell death in senescent cells ).
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The BH3 mimetic ABT-737 is a potent inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-XL, and Bcl-w. The Bcl-2 family modulates sensitivity to anticancer drugs in many cancers, including melanomas. In this study, we examined whether ABT-737 is effective in killing melanoma cells either alone or in combination with a proteasome inhibitor already in clinical use (Bortezomib) in vitro and in with ABT-737 and navitoclax, drugs that have both shown activity in the ex vivo treatment of AML cell lines and AML primary patient samples and in human clinical trials ( 15 ). The second goal is to determine whether BH3 proﬁ ling can be used as a tool to predict cellular response to ABT-199 treatment. In order to make a distinction between documents applicable to clinical trials authorised under Directive 2001/20/EC (i.e.
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Information about actively enrolling, ongoing, and completed clinical trials of cancer prevention, early detection, and supportive care, including phase I, II, and III agent and action trials and clinical trials management. | COVID-19 is an
Connect with NIA Sign up to receive updates and resources delivered to your inbox. Learn how to gather details about your cancer, places to search for clinical trials, how to narrow your search, and questions to ask to help you find a trial that is appropriate for you. Steps to Find a Clinical Trial Learn how to find the
Learn more about clinical trials and research at the Brady Urological Institute. We continue to monitor COVID-19 cases in our area and providers will notify you if there are scheduling changes.
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A clinical trial is a research study that involves people. These studies help doctors find better ways to treat and prevent cancer and other diseases.Why are clinical trials done?Clinical trials are the main way that doctors find better treatments. There are clinical trials for cancer and other diseases. Clinical trials also help doctors learn how to prevent disease or treat A clinical trial is a research study done to evaluate new medical approaches in people. HIV/AIDS clinical trials help researchers find better ways to prevent, detect, or treat HIV/AIDS.